28 Mar Cannabinoid Bio-Availability
According to most cannabinoid studies, vaping and smoking deliver the highest percentage of cannabinoids into the bloodstream, followed by sublingual applications via extracts, with ingestion at the bottom of the bioavailability curve.
We recommend to our customers to purchase our tinctures and take sublingually (hold under the tongue for 30-60 sec.) for the most effective results.
The bottom line is that our customers, see good results for the most part, once they find the potency that they need, whatever the actual level of bio-availability is. So, for example, if someone is taking a 1000 mg tincture, say 33.3 mg per day, and it is working well for them, then even if they are only actually getting 35% into their bloodstream sublingually, then that 11.6 mg is actually what they needed. We may really be getting much more than 35%, but the person is getting what they need, or they increase the dosage or potency until they do.
We strongly suspect that because of our approach of producing a full plant extract, full spectrum product, that the natural balance of the many compounds occurring in the plant such as cannabinoids, terpenes, flavonoids, ketones, fatty acids, vitamins and minerals is more closely preserved, which aids the human body in better absorption at the time of ingestion by whatever method. Our customer’s good results seem to bear that out versus much poorer results with isolates and distillates.
One study said that “Ingesting CBD, despite being the easiest method of delivery, is not particularly efficient at absorbing CBD in high concentrations and can take as long as two hours to work. However, another study (Huestis, 2009), also published by the U.S. National Library of Medicine, suggests that swallowing CBD with fatty acids may bypass this “first pass effect” and increase absorption rates of CBD after ingestion.
Our oils are in a base of MCT Oil, which contains fatty acids caprylic, capric and lauric acid. We strongly believe that our base helps with absorption as well.
Another study furthers the evidence that MCT oil (Coconut Oil) and other fatty acids enhance cannabinoid bio-availability.
“According to a study conducted by the University of Nottingham, fatty acids and medium to long chain triglycerides increase bio-availability the best. These foods, firstly, act as binding agents. The CBD is able to attach to them. The fats are metabolized into energy and they take the CBD along with it. This means that the CBD can then avoid being reduced by first metabolism. They are burned with these fats for immediate use. When CBD was used simultaneously with these foods, bio-availability increased by four times as much.”
They suggested consuming: Coconut oil, Olive oil, Soybean oil (Avoid this – very unhealthy!), Sesame oil, Fish, Nuts, Avocado, Meat and Eggs
We suggest people consume good sources of Omega-3, 6 and 9 fatty acids along with our products, such as various fish, mackerel, salmon, trout, cod liver oil, herring, oysters, sardines, anchovies, caviar, and seeds such as flax seeds, hemp seeds, pumpkin seeds, sesame seeds, chia seed, and nuts such as Brazil nuts, almonds, peanuts, pecans, cashews, pistachios, hazelnuts, macadamia nuts, walnuts, avocados, oils such as coconut oil, olive oil, flax seed oil, sesame oil, hemp seed oil, sesame oil and certain dark green leafy vegetables, including kale, spinach, purslane, mustard greens, and collards.